Recent publications:

 

​Erdoğan, A. N., Dasmeh, P., Socha, R. D., Chen, J. Z., Life, B. E., Jun, R., ... & Tokuriki, N. (2024). Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype. Nature Communications, 15(1), 10813.

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Bigge, J., Koebbe, L. L., Giel, A. S., Bornholdt, D., Buerfent, B., Dasmeh, P., ... & Schumacher, J. (2024). Expression quantitative trait loci influence DNA damage-induced apoptosis in cancer. BMC genomics, 25(1), 1-13.

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Trenkwalder T, Maj C, Al-Kassou B, Debiec R, Doppler SA, Musameh MD, Nelson CP, Dasmeh P, Grover S, Knoll K, Naamanka J. "Distinct genetic risk profile in aortic stenosis compared with coronary artery disease." JAMA cardiology (2024).

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​Giel, A. S., Bigge, J., Schumacher, J., Maj, C., & Dasmeh, P. (2024). Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity Across Polygenic Phenotypes. Molecular Biology and Evolution, 41(7). 

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Dasmeh, P., Zheng, J., Erdoğan, A.N. et al. (2024). Rapid evolutionary change in trait correlations of single proteins. Nature Communications, 15, 3327. 

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Schmutzer, M., Dasmeh, P., & Wagner, A. (2024). Frustration can Limit the Adaptation of Promiscuous Enzymes Through Gene Duplication and Specialisation. Journal of Molecular Evolution, 1-17.

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Maj, C., Eberts, A., Schumacher, J., & Dasmeh, P. (2024). Single-cell analysis reveals the spatial-temporal expression of genes associated with esophageal malformations. Scientific Reports, 14(1), 3752.

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Ranganathan, S.*, Dasmeh, P.*, Furniss, S., & Shakhnovich, E. (2023). Phosphorylation sites are evolutionary checkpoints against liquid–solid transition in protein condensates. Proceedings of the National Academy of Sciences, 120(20), e2215828120 (Equal Contribution).

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Karve, S., Dasmeh, P., Zheng, J., & Wagner, A. (2022). Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability. Nature Ecology & Evolution, 6(8), 1155-1164.

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Dasmeh, P., & Wagner, A. (2022). Yeast proteins may reversibly aggregate like amphiphilic molecules. Journal of Molecular Biology, 434(2), 167352.

 

Dasmeh, P., Doronin, R., & Wagner, A. (2022). The length scale of multivalent interactions is evolutionarily conserved in fungal and vertebrate phase-separating proteins. Genetics, 220(1), iyab184.

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Razban, R. M., Dasmeh, P., Serohijos, A. W., & Shakhnovich, E. I. (2021). Avoidance of protein unfolding constrains protein stability in long-term evolution. Biophysical Journal, 120(12), 2413-2424.

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Dasmeh, P., & Wagner, A. (2021). Natural selection on the phase-separation properties of FUS during 160 my of mammalian evolution. Molecular biology and evolution, 38(3), 940-951.

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Valsecchi, C. I. K., Basilicata, M. F.,..., Dasmeh, P. & Akhtar, A. (2021). RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature, 589(7840), 137-142.