Evolutionary and Functional Genomics

We are a computational biology lab studying the evolution and regulation of human complex traits. Our research combines genomic data, single-cell transcriptomics, and proteomics to investigate how gene regulation and molecular interactions shape phenotypic variation. Based at the Center for Human Genetics at Marburg University and Universitätsklinikum Marburg, we are particularly interested in the genetic architecture of polygenic traits and the biological interpretation of genome-wide association signals. We aim to understand how molecular interaction networks influence the distribution of genetic effects across the genome and across cell types. Our methods span next-generation sequence analysis, network-based modeling, and molecular simulations. By integrating these approaches, we seek to contribute to a deeper understanding of the mechanisms underlying human traits and their evolution.