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• January 2025: Our collaborative paper with Tokuriki lab (University of British Columbia), and Serohijos Lab (University of Montreal) is now out in Nature Communications.

• December 2024: The work led by Dr. Jessica Bigge on eQTL analyses for DNA damage response is now out in BMC Genomics. 

• November 2024: Our collaboration on the genetic risk profile of aortic stenosis with a consortium led by Prof. Schumacher, Dr. Maj and Dr. Trenkwalder is out in JAMA Cardiology.

• October 2024: We will teach the praktikum part of the course "molecular underpinnings of genetic diseases" on the single-cell analysis of gene expression with a focus on brain cell types.

• August 2024: Our paper on the analysis of evolutionary rate and expression level of genes associated with complex human phenotypes is our in Molecular Biology and Evolution.

• May 2024: We welcome Frough Babury from Studienkolleg Mittelhessen, Giessen to our lab. Frough will join us for a praktikum/internship and will study behavioural genetics with a focus on bipolar disorder.

• April 2024: Our work on the evolution of trait correlation in single proteins is out in Nature Communications. This was a fascinating collaboration with Tokuriki lab (University of British Columbia) and Zheng lab (Westlake University), initiated in Wagner lab (University of Zurich), and funded by Swiss National Science Foundation and German ministry of education and research (BMBF).

• March 2024: Our collaborative paper on the evolution of promiscuous enzymes with Wagner Lab. at the university of Zurich is out in the Journal of Molecular Evolution.

• February 2024: Antonia's paper on single-cell preferential expression of genes associated with esophageal malformations is out in Scientific Reports. Congratulations!

• January 2024: We will teach in the course "leveraging molecular databases for variant interpretation" with our colleague Dr. Carlo Maj from 09.01 to 12.01 in the seminar room 00/19350 at UKGM site. Pouria's part will be focused on functional genomics and how pathological missense variants affect proteins. The course material is accessible here.

• January 2024: Ehsan Tamandeh joined our lab as a research intern. Ehsan holds a M.Sc. degree in condensed matter physics from Isfahan University of Technology and will work on the network topology of gene interactions that underlie human polygenic traits.

• December 2023: Our portal for studying the evolutionary rate and the expression level of genes associated with human polygenic traits is public (www.evopolygen.de). We created this resource to help hypothesis generation for the evolution of genes associated with human polygenic traits.

• November 2023: Pouria will teach in the courses Bioinformatics (bio390) and Evolutionary Biology (bio351) as a guest lecturer at the University of Zurich. 

• October 2023: We welcome Rayhona to our Institute! Rayhona will work on the cell type-specific expression of membrane-less organelles in the brain. 

• July 2023: Pouria will give a talk in the EMBL conference and workshop on predicting evolution in Heidelberg!

• June 2023: How phase-separating proteins self-assemble while avoiding a transition to pathological aggregates? Read the public outreach piece about our recent collaboration with the Shakhnovich Lab here.

• June 2023: Pouria will present an e-poster at the European Society of Human Genetics conference in Glascow.

• May 2023: Our collaboration with Eugene Shakhnovich Lab at Harvard is out in PNAS. 

• May 2023: Pouria will teach a section on "proteins and protein networks" in the course molecular basis of genetic diseases offer by our institute at UKGM medical center and Marburg University.

• April 2023: We welcome Antonia to our lab and institute. Antonia will work on the single-cell analysis of neuronal cell populations. 

• March 2023: The preprint of our collaboration with Tokuriki Lab at University of British Columbia is out! Check it here.

• Jan 2023: Pouria has joined the center for human genetics as a group leader. Our research will be focused on computational and evolutionary medicine with a focus on single-cell transcriptomics.